Reply to “Commentary: ‘No Genetic Causality between Tobacco Smoking and Venous Thromboembolism: A Two-Sample Mendelian Randomization Study’ ”

作者：Hong-Cheng Du, Yunfei Zheng, Meng‐Qi Shen, Bai-Yang Deng · 发表于：Thrombosis and Haemostasis · 年份：2024 · DOI：10.1055/s-0044-1791679 · 研究领域：Genetic Associations and Epidemiology、Venous Thromboembolism Diagnosis and Management、Lipid metabolism and disorders

Letter to: Commentary: “No Genetic Causality between Tobacco Smoking and Venous Thromboembolism: A Two-Sample Mendelian Randomization Study” Thromb Haemost 2024; 124(12): 1169-1170 DOI: 10.1055/s-0044-1787653 Commentary: “No Genetic Causality between Tobacco Smoking and Venous Thromboembolism: A Two-Sample Mendelian Randomization Study” We recently received comments on our findings[ 1 ] from Liu et al for which we are grateful, and we appreciate their careful scholarship and thoughtfulness. We would like to respond to the comments of Liu et al as follows: First, Liu et al argue that a major issue in our study is the failure to account for sample overlap. However, as pointed out by Liu et al, the bias due to sample overlap is mainly due to false-positive errors, whereas our findings are not significant. However, we also replaced venous thromboembolism (VTE) data from different data sources ([ Table 1 ])[ 2 ] for validation in this response, and the results showed that our conclusions were stable ([ Table 2 ]). Table 1