Role of complement factor D in cardiovascular and metabolic diseases

作者：Yingjin Kong, Naixin Wang, Zhonghua Tong, Dongni Wang, Penghe Wang, Qiannan Yang, Xiangyu Yan, Weijun Song, Zexi Jin, Maomao Zhang · 发表于：Frontiers in Immunology · 年份：2024 · DOI：10.3389/fimmu.2024.1453030 · 被引用次数：24 · 研究领域：Complement system in diseases、Phagocytosis and Immune Regulation、Apelin-related biomedical research

In the genesis and progression of cardiovascular and metabolic diseases (CVMDs), adipose tissue plays a pivotal and dual role. Complement factor D (CFD, also known as adipsin), which is mainly produced by adipocytes, is the rate-limiting enzyme of the alternative pathway. Abnormalities in CFD generation or function lead to aberrant immune responses and energy metabolism. A large number of studies have revealed that CFD is associated with CVMDs. Herein, we will review the current studies on the function and mechanism of CFD in CVMDs such as hypertension, coronary heart disease, ischemia/reperfusion injury, heart failure, arrhythmia, aortic aneurysm, obesity, insulin resistance, and diabetic cardiomyopathy.