Self-adaptive epidermal blood flow sensor for high-flux vascular access monitoring of hemodialysis patients

作者：Yuqi Tian, Kai Yang, Y. Wang, Jie Wang, Andrea S. Carlini, Zhinan Zhang, Yujun Deng, Jinyun Tan, Linfa Peng, Bo Yu, Zhongqin Lin · 发表于：npj Flexible Electronics · 年份：2024 · DOI：10.1038/s41528-024-00342-y · 被引用次数：11 · 研究领域：Central Venous Catheters and Hemodialysis、Intravenous Infusion Technology and Safety、Hemodynamic Monitoring and Therapy

Well-functioning vascular access (VA) is essential for hemodialysis treatment in patients with end-stage renal disease (ESRD). However, continuous and accurate monitoring of blood flow to assess high-flux VA during hospitalization or at home is not feasible for either clinical instruments or wearable sensors. Here, we report the design and preclinical validation of a high-precision, long-term, epidermal blood flow sensor that self-adapts to unavoidable sensor-mounting deviations on the skin and is compatible with individual tissue differences. Specifically, the technology is based on thermal dissipation of the skin, and improves the signal-to-error ratio surpassing 4 times when measuring high-flux blood (100–600 mL/min). In preclinical validation, the sensor is compared with the Doppler ultrasound and demonstrate a blood flow resolution of 10–50 mL/min. Furthermore, it is highly-integrated and wearable, measuring 36 × 50 mm 2 . The sensor paves the way for accurate, convenient, high-flux blood monitoring, offering significant potential to extend the lives of patients with ESRD.