The association between serum S100β levels and prognosis in acute stroke patients after intravenous thrombolysis: a multicenter prospective cohort study

作者：Yang Qu, Hang Jin, Reziya Abuduxukuer, Shuang Qi, Xiang‐Kun Si, Peng Zhang, Kejia Zhang, Siji Wang, Xiangyu Zheng, Yu Zhang, Jianhua Gao, Xiankun Zhang, Xiaodong Liu, Chunying Li, Guangcai Li, Junmin Wang, Huimin Jin, Ying He, Ligang Jiang, Liang Liu, Yongfei Jiang, Rui-Hong Teng, Yan Jia, Bai-Jing Zhang, Zhibo Chen, Yingbin Qi, Xiuping Liu, Li Song, Xin Sun, Thanh N. Nguyen, Yi Yang, Zhen‐Ni Guo, on behalf of the Biomarkers of Brain Injury Investigator Study Group, Lijuan Wang, Yumei Chen, Yang Zheng, Zhi-Mei Yuan, Dongsheng Ju, Yun-Fei Ba, Jinhua Chen, Jiliang Gu, Anying Wang, Li-Li Zhao, Chen-Peng Dong, Li Liu, Zhong-Rui Pei, Shuang Yu, Xue Liu, Chun-Li Jiang, Ling He, Sun-Juan Zhang · 发表于：BMC Medicine · 年份：2024 · DOI：10.1186/s12916-024-03517-6 · 被引用次数：9 · 研究领域：S100 Proteins and Annexins、Acute Ischemic Stroke Management、Intracerebral and Subarachnoid Hemorrhage Research

BACKGROUND: S100β is a biomarker of astroglial damage, the level of which is significantly increased following brain injury. However, the characteristics of S100β and its association with prognosis in patients with acute ischemic stroke following intravenous thrombolysis (IVT) remain unclear. METHODS: Patients in this multicenter prospective cohort study were prospectively and consecutively recruited from 16 centers. Serum S100β levels were measured 24 h after IVT. National Institutes of Health Stroke Scale (NIHSS) and hemorrhagic transformation (HT) were measured simultaneously. NIHSS at 7 days after stroke, final infarct volume, and modified Rankin Scale (mRS) scores at 90 days were also collected. An mRS score ≥ 2 at 90 days was defined as an unfavorable outcome. RESULTS: A total of 1072 patients were included in the analysis. The highest S100β levels (> 0.20 ng/mL) correlated independently with HT and higher NIHSS at 24 h, higher NIHSS at 7 days, larger final infarct volume, and unfavorable outcome at 3 months. The patients were divided into two groups based on dominant and non-dominant stroke hemispheres. The highest S100β level was similarly associated with the infarct volume in patients with stroke in either hemisphere (dominant: β 36.853, 95% confidence interval (CI) 22.659-51.048, P < 0.001; non-dominant: β 23.645, 95% CI 10.774-36.516, P = 0.007). However, serum S100β levels at 24 h were more strongly associated with NIHSS scores at 24 h and 3-month unfavorable outc...