Unveiling the crucial role of ferroptosis in host resistance to streptococcus agalactiae infection

作者：Jia-Xuan Yi, Zeyu Sun, Peng Liu, Yuhang Wang, Hui Liu, Qingyu Lv, Decong Kong, Wenhua Huang, Yuhao Ren, Qian Li, Yongqiang Jiang, Jing Li, Hua Jiang · 发表于：Cell Death Discovery · 年份：2024 · DOI：10.1038/s41420-024-02189-8 · 被引用次数：6 · 研究领域：Inflammasome and immune disorders、Ferroptosis and cancer prognosis、RNA modifications and cancer

IL-1β represents an important inflammatory factor involved in the host response against GBS infection. Prior research has suggested a potential involvement of IL-1β in the process of ferroptosis. However, the relationship between IL-1β and ferroptosis in the context of anti-GBS infection remains uncertain. This research demonstrates that the occurrence of ferroptosis is essential for the host's defense against GBS infection in a mouse model of abdominal infection, with peritoneal macrophages identified as the primary cells undergoing ferroptosis. Further research indicates that IL-1β induces lipid oxidation in macrophages through the upregulation of pathways related to lipid oxidation. Concurrently, IL-1β is not only involved in the initiation of ferroptosis in macrophages, but its production is intricately linked to the onset of ferroptosis. Ultimately, we posit that ferroptosis acts as a crucial initiating factor in the host response to GBS infection, with IL-1β playing a significant role in the resistance to infection by serving as a key inducer of ferroptosis.