Neutrophil extracellular traps and cardiovascular disease: Associations and potential therapeutic approaches

作者：Yiyue Tang, Yang Jiao, Xiaohua An, Qingxian Tu, Qianfeng Jiang · 发表于：Biomedicine & Pharmacotherapy · 年份：2024 · DOI：10.1016/j.biopha.2024.117476 · 被引用次数：32 · 研究领域：Neutrophil, Myeloperoxidase and Oxidative Mechanisms、Nitric Oxide and Endothelin Effects、Inflammation biomarkers and pathways

Cardiovascular disease (CVD) is a significant global health concern, ranking among the top five causes of disability-adjusted life-years (DALY) in 190 countries and territories. Neutrophils, key players in the innate immune system, combat infections by releasing neutrophil extracellular traps (NETs) composed of DNA, histones, elastase, myeloperoxidase, and antimicrobial peptides. This paper explores the relationship between NETs and cardiovascular diseases, focusing on conditions such as heart failure, pulmonary hypertension, atrial fibrillation, and ischemia-reperfusion injury. Particularly, it delves into the impact of NETs on atrial fibrillation and pulmonary hypertension, as well as the role of myeloperoxidase (MPO) and neutrophil elastase (NE) in these diseases. Furthermore, the potential of targeting NETs for the treatment of cardiovascular diseases is discussed.