Pyroptosis induced by natural products and their derivatives for cancer therapy

作者：Yingfei Wen, You Li, Binbin Li, Peng Liu, Miaojuan Qiu, Zihang Li, Jiaqi Xu, Bo Bi, Shiqiang Zhang, Xinyi Deng, Kaiyuan Liu, Shangbo Zhou, Qiang Wang, Jing Zhao · 发表于：Biomaterials Science · 年份：2024 · DOI：10.1039/d4bm01023j · 被引用次数：11 · 研究领域：Inflammasome and immune disorders、Gout, Hyperuricemia, Uric Acid、Toxoplasma gondii Research Studies

Natural products, which are compounds extracted and/or refined from plants and microbes in nature, have great potential for the discovery of therapeutic agents, especially for infectious diseases and cancer. In recent years, natural products have been reported to induce multiple cell death pathways to exhibit antitumor effects. Among them, pyroptosis is a unique programmed cell death (PCD) characterized by continuous cell membrane permeability and intracellular content leakage. According to the canonical and noncanonical pathways, the formation of gasdermin-N pores involves a variety of transcriptional targets and post-translational modifications. Thus, tailored control of PCD may facilitate dying cells with sufficient immunogenicity to activate the immune system to eliminate other tumor cells. Therefore, we summarized the currently reported natural products or their derivatives and their nano-drugs that induce pyroptosis-related signaling pathways. We reviewed six main categories of bioactive compounds extracted from natural products, including flavonoids, terpenoids, polyphenols, quinones, artemisinins, and alkaloids. Correspondingly, the underlying mechanisms of how these compounds and their derivatives engage in pyroptosis are also discussed. Moreover, the synergistic effect of natural bioactive compounds with other antitumor therapies is proposed as a novel therapeutic strategy for traditional chemotherapy, radiotherapy, chemodynamic therapy, photodynamic therapy, photot...