Single Atom‐Engineered 2D Catalytic Nanosheets for Sonocatalytic Suppression of Orthotopic Clear Cell Renal Cell Carcinoma

作者：Houliang Zhang, Yifan Zhang, Weidong Song, Weipu Mao, Li Ding, Shuqiu Chen, Meiqi Chang, Dewei Zhao, Wei Feng, Yu Chen, Bo Peng · 发表于：Advanced Functional Materials · 年份：2024 · DOI：10.1002/adfm.202414302 · 被引用次数：6 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Photocatalysis Techniques、Organ Donation and Transplantation

Abstract Clear cell renal cell carcinoma (ccRCC), a prevalent malignant tumor, exhibits resistance to chemotherapy, necessitating advanced therapeutic approaches. Sonocatalytic therapy has emerged as a promising non‐invasive treatment for solid tumors due to its ability to penetrate deep tissue. Herein, the development of single atomic Au‐doped 2D TiO 2 nanosheets are presented with oxygen vacancies (Au‐SA/Def‐TiO 2 , ASDT) for sonocatalytic treatment of ccRCC. Surface defects on TiO 2 nanosheets effectively stabilize Au single atomic sites via the Ti‐Au‐Ti structure, enhancing catalytic properties and facilitating reactive oxygen species (ROS) generation by reducing energy barriers and improving electron (e − ) and hole (h + ) separation. Additionally, ASDT exhibits peroxidase‐like activities, further augmenting ROS production, leading to significant inhibition of tumor growth in subcutaneous and orthotopic ccRCC models under ultrasound irradiation. This study underscores the efficacy of defect engineering for stabilizing single atoms to boost ROS production and achieve effective tumor eradication by the enhanced sonocatalytic effect.