Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia

作者：Gerard Portela, Jeffrey L. Carson, Sonja A. Swanson, John H. Alexander, Paul C. Hébert, Shaun G. Goodman, Philippe Gabríel Steg, Marnie Bertolet, Jordan B. Strom, Dean Fergusson, Tabassome Simon, Harvey D. White, Howard A. Cooper, J. Dawn Abbott, Sunil V. Rao, Bernard Chaitman, Christopher B. Fordyce, Renato D. Lópes, Benoit Daneault, Maria M. Brooks, MINT Investigators, Adam C. Salisbury, Adam Gershon, Adedayo Adeboye, Adriana Carbonaro, Adriano Caixeta, A. Garvey Rene, Agnes Lee, Ahmad Mizyed, Ahmed Hassanin, A. Kone, A. Cherian, Akshay Bagai, Alana Gulliver, Aleisha Easton, Alexandra Rousseau, Alexandre Gautier, Alexandre Schaan de Quadros, Alexia Dantigny, Alexia Ep, Ali Ghamraoui, Alice Jacobs, Aline Giacomo, Allison Schley, Amanda Barnett, Amanda Bollino, Amanda Logan, Amanda Salvatore, Amanda Tice, Amandine Grelier, Amandine Ruissel, Ameen Patel, Ami Patel, Amina Zamiti-Smondel, Amy McMeans, Andrea Sarafolean, Andrew Baker, Andrew M. Goldsweig, Andrew P. DeFilippis, Andrew Starovoytov, Angeline Camilo, Angélique Andrieu, Angie Adler, Anh-Phuong Pham, Anna Helena Felipe Pereira Centurione, Anna Koulova, Anna S. Law, Anna Tran, Anne Druart, Antoine Fayol, Antoine Léquipar, Anuritha Tirumani, Anushka Jayasekara, Araceli Boan, Arav Jhand, Ariel Diaz, Arlete Matos, Arnaud Ferrante, Arthur Bracey, Arthur Darmon, Arthur Ramonatxo, Asha Aravind, Asha Mellor, Ashley Armstrong, A. Adam, Ata ur Rehman Quraishi, Attílio Galhardo, Audrey Cailliau, Aurélie Gutehrle, Axelle Fuentes, Barbara Gallagher, Barbara A. Konkle, Barbara Shannon, Barbara Shimada-Krouwer, Barinder Hansra, Barry H. Kaplan, Barry F. Uretsky, Basile Verdier, Batric Popovic, Baya Mahtout, Behram Mody, Benoit Daneault, Benoît Lattuca, Bernadette Fernando, Bernard Kadosh, Bernard Chaitman, Bhisham Harchandani, Blaire Cain, Brandon Dilluvio, Brandon M. Herbert, Brandy Williams, Brendan Duffy, Brian Corbett, Brian J. Potter, Bruna Machado, Bryan Marais, C. Pacheco, Camila Richter, Camilla de Oliveira Vieira, Camille A. Correia, Camille Granger, Carina Benson, Carl D. Reimers, Carl-Éric Gagné, Carlos Alberto Kenji Nakashima, Carlos L Alviar, Carlos Rochitti, Carolina Rodríguez Álvarez, Caroline Alsweiler, C. Boudreault, Caroline Vallières, Carolyn Jackson, Cassandra D. Josephson, Cassandra Reynolds, Cassie Wagner, Catalin Toma, Catherine Bouffard, C. Cruickshank, Catherine Drovetsky, Catherine Gordon, Catherine Levy, Cathrine Patten, Cathy Vickers, Céline Boucher, Celine Yan, Charlotte McNab, Charmaine Dias, Chelsey Snyder, Chloé Bonneton, Christel Simard, Christel Vassaliere, Christina Avena-Cyr, Christina Sattler, C. Hincks, Christophe Aucan, Christophe Thuaire, Christophe Tron, Christopher B. Fordyce, Christopher P. Stowell, Chuen Siang Low, Cindy Prié, Claire Bouleti, Claire Marie Pedroso Dias Corsini, Claire Vézier, Claudia Eaton, Claudia P. Hochberg, Claudine Robert, Clémence Charlon, Clément Servoz, Coralie Gasc, Corine Thobois, Craig Basman, Craig Hudak, Cristina Brueggeman, Cristina Carvalho Neuenshwander, Cristina Correa, Dalton Bertolim Précoma, Danica Kistanna, Daniel Johnson, Danieli Frassatto, Darby Thompson, Dário Celestino Sobral Filho, Darlene Ramadan, Darrell J. Triulzi, Darrell J. Triulzi, Dávid Barton, David Brieger, David Cohen, David M. Dudzinski, David Fillmore, David S. Kountz, David Laflamme, David Landers, David S. Shin, Dean Fergusson, Deanna Ravenscraft, Deborah S. Keller, Deborah McCloskey, Deborah Ramsey, Deepak Bhatt, Delphine Béziau-Gasnier, Denis Angoulvant, Denise Fine, Derek P. Chew, Dharshini Sivakumaran, Dhvni Dave, Diana Albers, Diana Gatland, Dinesh Kalra, Djedjiga Naudin, Djouher Firoud, Donna Stoliker, Doreen Singh, Dounia Boumahni, Eldad A. Hod, Eliane Sehnem, Elias Iliadis, Elizabeth Coccio, Elizabeth C. Martin, Elizabeth C. Nowak, Elizabeth A. Reedy, Ella Zadorozny, Ellen Cerullo, Elodie Delelo, Élodie Drouet, Émile Ferrari, Emilie Collet, Emilie Sau, Emilie Tachot, Emily Pierce, Emily Strober, Emma Kleemann, Emma Reynolds, Éric Durand, Eric Leifer, Eric McCamant, Erin Morton, Erin Siderio, Erin N. Smith, Ervin Mazniku, Estefanía Hernández, Estêvão Lanna Figueiredo, E Fourrier, Étienne Puymirat, Eugene Yuriditsky, Eunice Nubret, Fabien Huet, Fábio Rodrigues de Oliveira, Fabrice Ivanes, Faraaz Quraishi, Farhad Abtahian, Fatemeh Vaezi-Poor, Fatima Benattia, Fatna Benettaib, Federica Scialo Véronique Pignot, Fei Chen, Fernando Carvalho Neuenschwander, Fernando De Martino, Fiona Wollaston, F. Bichât, Fnu Namrata, Frances O. Wood, Francisco Campelo-Parada, François Martin Carrier, François Roubille, Frédéric Bouisset, Frederico Toledo Campo Dall’Orto, Friederike K. Keating, Furquan Khattak, Gabriela De Jesus, Gaetana Cosentino, Gamintha Nanayakkara, Ganesh Raveendran, Gau Shoua Vue, Gautier Desmoulin, Genevieve Dallaire, George Sopko, George Younis, Georgia Beatriz Oliveira Damásio, Gérald Vanzetto, G Ricafort, Gerard Portela, Gilberto De Freitas, G. Barone Rochette, Gilles Lemesle, Gislayne Rogante Ribeiro, Giulia Bonatto, Graham S. Hillis, Greg Schnell, Gregary Marhefka, Gregory W. Barsness, Grégory Ducrocq, Gregory Maniatis, Gretchen Bernardini, Gyan Sandhu, Hal S. Wasserman, Hannah Hunsaker, Hardeep Dholiya, Harsha Adnani, Harvey D. White, Hasina Rakotosamimanana, Heidi Testa, Helaine Noveck, Hélène Abergel, Herbert D. Aronow, Himantha De Silva, Hinde Irekti, Hope Wolf, Houda El Banna, Howard A. Cooper, Hussein Beydoun, Ian Crozier, Ian Dalangin, Ian Ternouth, Imants Rubenis, Imrana Khalid, Irène Garcia Ramos, Isabelle Chausse, Isabelle Pilat, Isabelle Roy, Israel Cabral, Ivana Hunt, Izabela Rodarte Falco, J. Dawn Abbott, Jackie Chow, Jackson Ng, Jacob C. Jentzer, Jacqueline Hare, Jae Sung Lee, James Sullivan, Jamie Hall, Jan O. Friedrich, Janah Aji, Jane Eckstein, Janek Senaratne, Janet R. Bogan, Jasjit Bhinder, Jason Scott, Javier Molina-Martín de Nicolás, Jay S. Raval, Jay H. Traverse, Jayakumar Sreenivasan, Jean Guillaume Dillinger, Jean-François Naud, Jeanne Varlot, Jean‐Pierre Déry, Jeffrey L. Carson, Jeffrey Ogbara, Jenifer Kaufman, Jennifer Gilmore, Jennifer LaLonde, Jennifer A. Moore, Jennifer Nguyen, Jennifer Nickol, Jennifer M. Ratcliffe, Jennifer C. Stevenson, Jenny Petterson, Jenny Whitehead, Jeremy Stone, Jesse Byrd, Jessica Breistroff, Jéssica Ribeiro, Jette Koelle, J. Somaratne, Jocelyn Kuber, Jocelyne Benatar, Johanne Silvain, John Ducas, John Elliott, John Graham, John H. Alexander, John V. Higgins, John Neary, Jonathan Doroshow, Jonathan Halevy, Jordan B. Strom, José Gildo de Moura Monteiro Júnior, Joseph M. Delehanty, Joseph Gutbrod, Joseph S. Rossi, Joshua Roark, Joshua Schulman‐Marcus, Joyce Umbelino S. Yamamoto, Judah Rauch, Judith Mondragon, Jules Mesnier, Julia Hoang, Juliana Vieira Garcia, Juliane Posson, Julie Caron, Julie Hildt, Julie Werra, Kaïna Mahmoudi, Kaitlyn Sternat, Kajenny Srivaratharajah, Kalon K.L. Ho, Kara Stout, Karen Dragert, Karen duBourg, Karen Maslowski, Karina De Carvalho Cordeiro, Kárita Cláudia Freitas Lidani, Katherine Coutu-Beaudry, Kathryn L. Weise, Kathy Aristy, Kathy S. Puntil, Katia Lassouani, Katia Ledra, Kay Knepper, Kayla Malchoff, Kellie Sherron, Kelly Franchetti, Kelly Lawrence, Kelly Mohr, Kemilys Marine Ferreira, Kevin R. Bainey, Kim M. Allen, Kimberly Lemoine, Kimberly Striler, Kiran Atwal, Kodangudi B. Ramanathan, Kristie Coleman, Kristin Fischer, Kristin Miller, Kristina Wippler, Krysten Gregus, Kunal Minhas, Kyle Agostini, KyungMann Kim, Lalantha Coonghe, LaMonica Daniel, Larissa Teixeira Aleixo Silva, Laura Cetran, Laura Johnson, Laura Tomat, Lauren Demerville, Lauren Lanuto, Laurence Bérard, Laurent Delorme, Laurie Dennis, Lea Cacoub, Leana Abreu, Leanne Harmann, Leonilda Castanho Da Rocha, Lesley A. Schmaltz, Leslie Poirier, Leslie Serchuck, Lília Nigro Maia, Lilian Mazza Barbosa, Liliane A.T. Arnaldi Seixas, Lillie Johnson, Lily Cai, Lina Fu, Linda Spearman, Lisa Trombetta, Lise Blais, Lori-Ann Desimone, L. David Hillis, Loukas Boutis, Luis Gruberg, Luiz Eduardo Fontelles Ritt, Lynda Argenzio, Lynne Uhl, M. Saint-Jalmes, Malek Kass, Mallory Hatfield, Manohara Senaratne, Mansi Oberoi, Mansoor Qureshi, M. Lombardero, Marcelo Arruda Nakazone, Margie Palazzolo, Margot Bobin, Maria Angélica Lemos, Maria Cleide Freire Clementino da Silva, Maria Daly, Maria Masih, Maria M. Brooks, Maria Pina Simula, Mariana Lopes, Marianna Deway Andrade Dracoulakis, Marie Delon, Marie Henault, Marilynn Roth, Marina Leniliot, Marine Poisay, Marine Servat, Marion Berous, Mark Menegus, Mark Schmidhofer, Marlene Santos, Marnie Bertolet, Martin Faucher, Martine Lebrasseur, M. J. ALBRIGHT, Mary Wexler, Matt Cavender, Matthew L. Carlson, Matthew S. Karafin, Maud H.E. Jansen, Maximilien Saint-Gilles, Maya Hatwik, Maynara Martins, Meechai Tessalee, Megan Basch, Megan Gonzalez, Megan Littleton, Meghan Moore, Meghan Sesera, Mélanie Roy, Melissa Enlow, Mélissa Gagnon-Hamelin, Melissa D. Howard, Melissa Sears, Mélissa Sriwaran, Meriton Ruhani, Micah T. Prochaska, Michael Carson, Michael Gitter, Michael Goldfarb, Michael Hume, Michael C. Kontos, Michael Kutryk, Michael A. Thomas, Michel Zeitouni, Micheline Charron, Micheline Nantel, Michelle M. Bonner, Michelle Jordan, Miguel Barrero, Mike Hanninen, Mikhail Torosoff, Mina Madan, Miriam Schnorr Meloche, Mitchell W. Krucoff, Mohamed Labbaoui, Mohammed Hasan Khan, Mohammed Mouzouri, Mollie Machado, Molly Raftery, Mona Doorsian, Mouin Nasr, Muammar Abdulrahman, Muhammad Abubakar Shakir, Muhammad Iqbal, Mujeeb Sheikh, Nadhira Bennacer, Nadielly Prado, Najime Bouhzam, N Sánchez Fuentes, Naomi L.C. Luban, Naomi Uchida, Narimane Benhamadi, Nassim Redjimi, Natalia Alvaia, Natalia Cordeiro da Silva, Nathalie Berger, Nathalie Durand, Nathan Muhn, Neelam Dalman, N. Brass, Neil Fam, Neila Sayah, Nesrine Hafsi, Ngaire Meadows, Nicholas Brooks, Nick Bartlett, Nick Fisher, Nicolas Michaud, Nicolas Pham, Nidhya Lakshmi Thulasiraj, Nikki Procopi, Nilay Patel, Noelle Manning, Noora Reffat, N. Alvarez Garcia, Noreen Lounsbury, Norma Hogg, Norma Keller, Océane Crebier, O Ramírez, Olivia Bogdan, Olivier Barthélémy, Omar K. Siddiqi, Oreyane Tate, Osana Costa, O Carvalho, Osvaldo Da Silva Júnior, Pablo Cure, Pablo Mendoza, Pâmela Assunção, Paola Engelmann Arantes, Paolo Mascari, Parija Sharedalal, Paris Jamiel, Pascale Léon, Patricia Niblack, Patricia Power, Patricia Tyler, Patrick Desanto, Patty Noll, Paul C. Hébert, Paul Grunenwald, Paul Mullen, Paula Miranda Camasmie, Paula Santiago Teixeira, Pauline Peretout, Paulo Henrique Maia Vilela, Paulo Jhones Dutra, Payam Dehghani, Pedro Beraldo de Andrade, Pedro de Barros e Silva, Pedro Gabriel Melo de Barros e Silva, Perrine Devos, Perry Weinstock, Perwaiz Meraj, Peter Stone, Phil Tonkins, Philippe Gabriel Steg, Philippe Rheault, Pierre Coste, Poonam Velagapudi, Pranitha Patlolla, Puneet Gandotra, Queila Borges de Oliveira, Quentin Fischer, Rabab Bencherif, Rachel Elysee, Rachel Gentles, Rahman Shah, Raj C. Shah, Rajesh Gupta, Rajesh V. Swaminathan, Rajiv Jauhar, Ramin Ebrahimi, Raphael Boesche Guimarães, Raven R. Dwyer, Razi Khan, Rebecca Cairns, Rehana Bajwa, Reilly Ische, Renato D. Lópes, Renée Duclos, Reza Sahebjamei, Rhonda Norton, Ricardo Costa, Ricardo Reinaldo Bergo, Richard G. Bach, Richard Dima, Richard Haichin, Riona Timmons, Risheek Kaul, Robert C. Hendel, Robert O. Roswell, Róbson Alves Barbosa, R. Mercurio, Rodolfo Dourado, Rodrigo Cunha de Sousa, Romain André, Roman Royzman, Rose Peterson, Roukoz Abou-Karam, Ruth J. Stein, Ryan Orgel, Ryan Proc, Ryan Ruskamp, Sabiha Sultana, Samanta Baboolall, Samantha Macias, Samantha Smith, Samantha Weber‐Fishkin, Sameer Khandhar, Samer Sayyed, Samia Tamazi, Sammy Elmariah, Samraj Nandra, Sandra Kahlouche, Sandra Paco, Sara Blanc Vannet, Sara Jabeen, Sarah Arab, Sarah Hadjih, Sarah Preston, Sarah Whitsett, Sarang Kim, Sean Taylor, Serge Bureau, Sergio Nascimento, Shahab Ghafghazi, Shahab Pathan, Shahbaz A. Malik, Sharada Manchikanti, Sharon Vincent, Shaun G. Goodman, Sheila Davila, Sheila Redding, Sheryl Kelsey, Sheryll Sorensen, Shirley Geok‐lin Lim, Shirley Pettit, Shuaib Ahmad, Sidney Gomes, Silvia Poleth, Simeoni Thomas, Simon Kirkham, Simon Robinson, Simon Topalian, Simone A. Glynn, Sohaib Virk, Solenn Catherine, Sonia Azzakani, Sophie Florencio, Soraya Merbah, Sorin J. Brener, Spencer Wikkerink, Srikanth Vallurupalli, Sripal Bangalore, Stacey Clegg, Stella Chan, Stephan Bierenga, Stéphane Manzo‐Silberman, Stephanie Frank, Stéphanie Marlière, Stéphanie Tribeau, Stephen Allan Schaffer, Steve Attanasio, S. Swe, Summer Nasr, Suneet Khurana, Sunil V. Rao, Sunil V. Rao, Susan Vallancey, Suzanne Welshsan, Sydney Thorsteinsson, Syed Haidry, Tabassome Simon, Taís Sarmento, Tamar S. Polonsky, Tara Tawil, Tatum Scholl, Taylor Johnson, Teresa L. Reed, Terry McPherson, Thaise Loverdi, Thao Huynh, Tharani Jeyaram, Thibaud Genet, Thibault Lhermusier, Thibaut Hemery, Thomas Baudinet, Thomas J. Povsic, Thomas Wallet, Tia Albro, Todd Wood, Tomy Salloum, Tracy L. Nicholson, Tyler Patterson, Tyrone Wade, Umar Rashid, Véléda Blesboi, Veronica Day, Victor Buzura, Victoria Tea, Vikas Tandon, Vincent Spagnoli, Vladimír Džavík, Warren K. Laskey, Wendy A. Stewart, William J. Kostis, William Lawson, William Matthai, Wilson Ginete, Xuming Dai, Yanek Pépin‐Dubois, Yann Rosamel, Yiannis S. Chatzizisis, Ying Tung Sia, Yogesh Sharma, Yogita Rochlani, Yola El Dahr, Yves Cottin, Zaria Starfeldt · 发表于：Annals of Internal Medicine · 年份：2024 · DOI：10.7326/m24-0571 · 被引用次数：17 · 研究领域：Blood transfusion and management、Erythropoietin and Anemia Treatment、Blood groups and transfusion

BACKGROUND: The optimal hemoglobin threshold to guide red blood cell (RBC) transfusion for patients with acute myocardial infarction (MI) and anemia is uncertain. OBJECTIVE: To estimate the efficacy of 4 individual hemoglobin thresholds (<10 g/dL [<100 g/L], <9 g/dL [<90 g/L], <8 g/dL [<80 g/L], and <7 g/dL [<70 g/L]) to guide transfusion in patients with acute MI and anemia. DESIGN: Prespecified secondary analysis of the MINT (Myocardial Ischemia and Transfusion) trial using target trial emulation methods. (ClinicalTrials.gov: NCT02981407). SETTING: 144 clinical sites in 6 countries. PARTICIPANTS: 3492 MINT trial participants with acute MI and a hemoglobin level below 10 g/dL. INTERVENTION: Four transfusion strategies to maintain patients' hemoglobin concentrations at or above thresholds of 10, 9, 8, or 7 g/dL. Protocol exceptions were permitted for specified adverse clinical events. MEASUREMENTS: Data from the MINT trial were leveraged to emulate 4 transfusion strategies and estimate per protocol effects on the composite outcome of 30-day death or recurrent MI (death/MI) and 30-day death using inverse probability weighting. RESULTS: The 30-day risk for death/MI was 14.8% (95% CI, 11.8% to 18.4%) for a <10-g/dL strategy, 15.1% (CI, 11.7% to 18.2%) for a <9-g/dL strategy, 15.9% (CI, 12.4% to 19.0%) for a <8-g/dL strategy, and 18.3% (CI, 14.6% to 22.0%) for a <7-g/dL strategy. Absolute risk differences and risk ratios relative to the <10-g/dL strategy for 30-day death/MI incre...