Prevalence of bronchiectasis in adults: a meta-analysis

作者：Lu Wang, Jiajia Wang, Guixiang Zhao, Jiansheng Li · 发表于：BMC Public Health · 年份：2024 · DOI：10.1186/s12889-024-19956-y · 被引用次数：22 · 研究领域：Cystic Fibrosis Research Advances、Gastroesophageal reflux and treatments、Voice and Speech Disorders

BACKGROUND: Bronchiectasis, once considered an orphan disease, is receiving attention globally owing to its increasing prevalence, healthcare burden, and associated morbidity. However, the prevalence of bronchiectasis is unclear. This meta-analysis estimates the prevalence of bronchiectasis in adults, providing a valuable reference for future research. METHODS: PubMed, Embase, Cochrane Library, and Web of Science databases were searched from inception to May 31, 2024 for studies reporting the prevalence of bronchiectasis. Study selection, data extraction, and overall analysis of risk of the retrieved studies were conducted independently by two authors. The tool for assessing the risk of bias in prevalence studies was used to evaluate overall risk. Stata software (version 15.1) was used to performed the meta-analysis. Subgroup and sensitivity analyses were conducted to identify the source of heterogeneity. Funnel plots combined with Egger's test were used to detect publication bias. RESULTS: The pooled prevalence of bronchiectasis in adults from 15 studies covering 437,851,478 individuals was 680 per 100,000 (95% CI: 634-727 per 100,000). Subgroup analysis showed that the prevalence of bronchiectasis in the United States, Korea, and China was 478 per 100,000 (95% CI: 367-588 per 100,000), 886 per 100,000 (95% CI: 778-993 per 100,000), and 759 per 100,000 (95% CI: 35-2399 per 100,000), respectively; 467 per 100,000 (95% CI: 416-518 per 100,000) in males and 535 per 100,000 (95%...