SO2F2 mediated click chemistry enables modular disulfide formation in diverse reaction media

作者：Hengzhao Li, Mengqi Peng, Junyu Li, Lijun Wang, Hainam Do, Ke Ni, Minlong Wang, Zhankui Yuan, Tianxiao Zhao, Xiaohe Zhang, Xiaoxu Zhang, Zhaonong Hu, Fazheng Ren, Jie An · 发表于：Nature Communications · 年份：2024 · DOI：10.1038/s41467-024-52606-w · 被引用次数：13 · 研究领域：Click Chemistry and Applications、Sulfur-Based Synthesis Techniques、Chemical Synthesis and Analysis

, which display exceptional selectivity toward disulfide formation through an effective nucleophilic substitution cascade. This reaction's unique characteristics satisfy the stringent click-criteria with its high thermodynamic driving force, straightforward conditions, wide scope, quantitative yields, exceptional chemoselectivity, and non-chromatographic purification process. The modular synthesis of symmetrical, unsymmetrical, cyclic and polydisulfides is demonstrated, along with the formation of disulfide cross-linked hydrogels.