Testicular fibrosis pathology, diagnosis, pathogenesis, and treatment: A perspective on related diseases

作者：Ying Xu, Poyi Hu, Wanyi Chen, Jin Chen, Chunyan Liu, Huiping Zhang · 发表于：Andrology · 年份：2024 · DOI：10.1111/andr.13769 · 被引用次数：18 · 研究领域：Testicular diseases and treatments、Sperm and Testicular Function、Multiple Myeloma Research and Treatments

Testicular fibrosis is a chronic and progressive condition characterized by the excessive deposition of extracellular matrix proteins. This process leads to fibrotic remodeling, damage to testicular tissue, and the irreversible loss of male reproductive function. However, there is currently a lack of comprehensive reviews systematically elucidating the pathology, diagnosis, pathogenesis, and treatment of testicular fibrosis from the perspectives of different related diseases. This review addresses these aspects of testicular fibrosis, with a particular emphasis on elucidating the underlying mechanisms of testicular cells. It provides insights that can be relevant for future research and clinical interventions.