Nickel-Catalyzed Cross-Coupling of Aziridines with Thioesters toward Atom-Economic Synthesis of β-Sulfanyl Amides

作者：Ni Qian, Xianmao Liu, Zhiyong Song, Yuanhong Ma · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c02823 · 被引用次数：5 · 研究领域：Synthesis and Catalytic Reactions、Sulfur-Based Synthesis Techniques、Catalytic C–H Functionalization Methods

Thioesters have been recognized as a class of powerful bifunctional reagents, namely, great donors of acyl and sulfide moieties. However, such application in value-added synthesis is still very limited to date. Herein, a nickel-catalyzed cross-coupling reaction system of aziridines with thioesters was developed under redox-neutral and mild conditions. This catalytic method provides an atom-economic route for the synthesis of diverse β-sulfanyl amide derivatives with wide substrate scope (43 examples), good functional group tolerance, and regioselectivity.