The effect of brain-computer interface controlled functional electrical stimulation training on rehabilitation of upper limb after stroke: a systematic review and meta-analysis

作者：Chunlin Ren, X. Li, Qian Gao, Mengyang Pan, Jing Wang, Fangjie Yang, Zhenfei Duan, Pengxue Guo, Yasu Zhang · 发表于：Frontiers in Human Neuroscience · 年份：2024 · DOI：10.3389/fnhum.2024.1438095 · 被引用次数：36 · 研究领域：EEG and Brain-Computer Interfaces、Stroke Rehabilitation and Recovery、Muscle activation and electromyography studies

Introduction Several clinical studies have demonstrated that brain-computer interfaces (BCIs) controlled functional electrical stimulation (FES) facilitate neurological recovery in patients with stroke. This review aims to evaluate the effectiveness of BCI-FES training on upper limb functional recovery in stroke patients. Methods PubMed, Embase, Cochrane Library, Science Direct and Web of Science were systematically searched from inception to October 2023. Randomized controlled trials (RCTs) employing BCI-FES training were included. The methodological quality of the RCTs was assessed using the PEDro scale. Meta-analysis was conducted using RevMan 5.4.1 and STATA 18. Results The meta-analysis comprised 290 patients from 10 RCTs. Results showed a moderate effect size in upper limb function recovery through BCI-FES training (SMD = 0.50, 95% CI: 0.26–0.73, I 2 = 0%, p < 0.0001). Subgroup analysis revealed that BCI-FES training significantly enhanced upper limb motor function in BCI-FES vs. FES group (SMD = 0.37, 95% CI: 0.00–0.74, I 2 = 21%, p = 0.05), and the BCI-FES + CR vs. CR group (SMD = 0.61, 95% CI: 0.28–0.95, I 2 = 0%, p = 0.0003). Moreover, BCI-FES training demonstrated effectiveness in both subacute (SMD = 0.56, 95% CI: 0.25–0.87, I 2 = 0%, p = 0.0004) and chronic groups (SMD = 0.42, 95% CI: 0.05–0.78, I 2 = 45%, p = 0.02). Subgroup analysis showed that both adjusting (SMD = 0.55, 95% CI: 0.24–0.87, I 2 = 0%, p = 0.0006) and fixing (SMD = 0.43, 95% CI: 0.07–0.78,...