Post-translational modification in the pathogenesis of vitiligo

作者：Lu Lu, Huimin He, Jindi Feng, Zhonghui Hu, Shiyu Zhang, Lu Yang, Yuehua Liu, Tao Wang · 发表于：Immunologic Research · 年份：2024 · DOI：10.1007/s12026-024-09545-x · 被引用次数：8 · 研究领域：melanin and skin pigmentation、Phytochemical compounds biological activities、Biochemical Analysis and Sensing Techniques

Vitiligo is a chronic dermatological condition marked by the loss of skin pigmentation. Its complex etiology involves multiple factors and has not been completely elucidated. Protein post-translational modification pathways have been proven to play a significant role in inflammatory skin diseases, yet research in the context of vitiligo remains limited. This review focuses on the role of post-translational modifications in vitiligo pathogenesis, especially their impact on cellular signaling pathways related to immune response and melanocyte survival. Current therapeutic strategies targeting these pathways are discussed, emphasizing the potential for novel treatments in vitiligo management.