Clinical and Prognostic Characteristics of Acute BAD–Related Stroke: A Multicenter MRI–Based Prospective Study

作者：Shengde Li, Lihua Wang, Bin Liu, Ping Zhang, Jiangtao Zhang, Guofang Chen, Qingsong Yang, Hong Bian, Xin Li, Jian Wu, Fengli Zhao, Shifu Liu, Hongying Bai, Weili Zhao, Wei Yue, Kai Feng, Yufeng Tang, Zhengqi Lu, Yusheng Li, Jingbo Zhang, Lixin Zhou, Yi‐Cheng Zhu, Jun Ni, Bin Peng, on behalf of BAD-Study Investigators · 发表于：Stroke · 年份：2024 · DOI：10.1161/strokeaha.124.047688 · 被引用次数：26 · 研究领域：Cerebrovascular and Carotid Artery Diseases、Acute Ischemic Stroke Management、Dementia and Cognitive Impairment Research

BACKGROUND: Branch atheromatous disease (BAD)-related stroke has emerged as a meaningful subtype of ischemic stroke yet remained understudied. We aimed to investigate the demographic, clinical, therapeutic, and prognostic characteristics of BAD-related stroke. METHODS: The BAD-study was a nationwide, multicenter, prospective, observational cohort study in 20 Chinese hospitals from June 2021 to June 2023, enrolling patients aged 18 to 80 years with BAD-related stroke within 72 hours of onset. Eligible single subcortical infarct in the territory of lenticulostriate artery and paramedian pontine artery was included. Clinical, laboratory, and treatment data were collected at baseline. The primary outcome was a proportion of good outcomes (modified Rankin Scale score, 0-2) at 90 days. Main secondary outcomes included early neurological deterioration (END), cerebrovascular event, major bleeding, and excellent outcome (modified Rankin Scale score, 0-1) during 90-day follow-up. RESULTS: We finally enrolled 476 patients, with a median age of 60 (interquartile range, 53-68) years, and 70.2% were male. The median National Institutes of Health Stroke Scale score was 3 (interquartile range, 2-6) at enrollment. Involvement of the lenticulostriate artery was more common than the paramedian pontine artery (60.7% versus 39.3%). END occurred in 14.7% of patients, with a median time from onset of 38 (interquartile range, 22-62) hours. The rates of good and excellent outcomes were 86.5% and 72%,...