Towards a unified theory of the aetiology of schizophrenia

作者：Yuchao Jiang, Xiao Chang, Jianfeng Feng · 发表于：The British Journal of Psychiatry · 年份：2024 · DOI：10.1192/bjp.2024.65 · 被引用次数：6 · 研究领域：Mental Health and Psychiatry、Schizophrenia research and treatment、Neurology and Historical Studies

We emphasise the existence of two distinct neurophysiological subtypes in schizophrenia, characterised by different sites of initial grey matter loss. We review evidence for potential neuromolecular mechanisms underlying these subtypes, proposing a biologically based disease classification approach to unify macro- and micro-scale neural abnormalities of schizophrenia.