Therapeutic effects of Lianhua Qingke on COPD and influenza virus-induced exacerbation of COPD are associated with the inhibition of NF-κB signaling and NLRP3 inflammasome responses

作者：Runfeng Li, Huihuang Deng, Han Yu, Yanan Tong, Yunlong Hou, Tao Huang, Mengjie Xiao, Lingzhu Deng, Xin Zhao, Yaorong Chen, Pei Feng, Ruifeng Chen, Zifeng Yang, Hui Qi, Zhenhua Jia, Feng Wei · 发表于：International Immunopharmacology · 年份：2024 · DOI：10.1016/j.intimp.2024.113213 · 被引用次数：9 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Inflammasome and immune disorders、Pediatric health and respiratory diseases

• LHQK can mitigate chronic pulmonary inflammation and structural damage, which are hallmarks of COPD progression. • LHQK also exhibits promising antiviral properties and immunomodulatory effects in H1N1-induced AECOPD models. • LHQK’s immunomodulatory effects is associated with the inhibition of NF-κB signaling and NLRP3 inflammasome responses. • LHQK could be a valuable therapeutic option for preventing and treating AECOPD in clinical settings. Lianhua Qingke (LHQK), a traditional Chinese medicine (TCM) used clinically for the treatment of respiratory diseases with acute tracheobronchitis, and cough, has demonstrated promising efficacy in suppressing inflammation, inhibiting mucin secretion, reducing goblet cell hyperplasia and maintaining airway epithelial integrity. However, its efficacy in managing chronic obstructive pulmonary disease (COPD) progression, particularly virus-induced acute exacerbations of COPD (AECOPD), remains unclear. Here, cigarette smoke (CS)-induced COPD and CS+virus (influenza H1N1)-triggered AECOPD mouse models were employed to evaluated the therapeutic potential of LHQK. The findings demonstrated that LHQK treatment led to significant improved pulmonary function, suppressed pulmonary inflammation, alleviated lung histopathological changes, and preserved airway epithelial integrity in COPD mice. Additionally, LHQK treatment effectively inhibited viral replication in the lungs of AECOPD mice and decreased recruitment of immune cells (M1 macrophages,...