Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial

作者：Huilian Duan, Ning Xu, Tong Yang, Moyan Wang, Chunlai Zhang, Jiangang Zhao, Zhenshu Li, Yongjie Chen, Jing Yan, Meilin Zhang, Wen Li, Zhongbao Yue, Fei Ma, Ruikun He, Guowei Huang · 发表于：Journal of Affective Disorders · 年份：2024 · DOI：10.1016/j.jad.2024.09.131 · 被引用次数：11 · 研究领域：Fatty Acid Research and Health、Neurological Disorders and Treatments、Nutrition and Health in Aging

Phosphatidylserine (PS) and α-Linolenic acid (ALA), are positively associated with cognitive function, but their combination effects and possible mechanisms remain unclear. We aimed to explore the effects on cognition and potential mechanism of the supplements. This randomized, double-blind, placebo-controlled trial recruited 190 MCI patients in Tianjin, China, and randomly assigned in intervention group and placebo group. Each group consumed two capsules every day for 12 months. Each capsule for intervention group contains 144 mg ALA, 31.5 mg PS and 3.6 mg Ginkgo total flavonoids as main functional components, with 0.48 mg Vitamin B 1 (as thiamine hydrochloride), 0.48 mg Vitamin B 6 (as pyridoxine hydrochloride) and 90 μg folic acid as supplement. Capsules for placebo group were identical but contain no active ingredients. Cognitive function, serum n-3 polyunsaturated fatty acids (PUFAs) and neurotransmitters were assessed at baseline and 12 months. Linear mixed effects model and causal mediation analysis were conducted to explore the effects and potential mechanism of the intervention. A total of 190 participants (mean [SD] age, 67.95 [5.62] years; 70 (36.8 %) male and 120 (63.2 %) female) were randomized to the placebo group ( n = 95) and intervention group (n = 95). Compared with placebo group, the intervention group had statistically significant improvements in arithmetic testing ( β , 0.688; 95 % CI , 0.103–1.274), the similarity test ( β , 1.070; 95 % CI , 0.472–1.667)...