Novel benzimidazole-based azine derivatives as potent urease inhibitors: synthesis, in vitro and in silico approach

作者：I. Ullah, Aftab Alam, Ahmed A. Elhenawy, Mumtaz Ali, Abdul Latif, Ajmal Khan, Ahmed Al‐Harrasi, Manzoor Ahmad · 发表于：Future Medicinal Chemistry · 年份：2024 · DOI：10.1080/17568919.2024.2401311 · 被引用次数：9 · 研究领域：Synthesis and Characterization of Heterocyclic Compounds、Synthesis and biological activity、Quinazolinone synthesis and applications

Aim: In light of various biological activities of benzimidazole and azines, this study focuses on reporting novel derivatives of benzimidazole nucleus.Methods: Twenty novel azines of benzimidazole were synthesized, characterized and tested for in vitro urease inhibitory activity.Results: All these derivatives showed excellent to good inhibition in the range of IC50 values 14.21 ± 1.87 to 76.11 ± 1.81 μM by comparing with standard thiourea 21.14 ± 0.42 μM. Docking studies were performed for the targeted benzimidazole derivatives to understand the binding mechanics. The results indicated higher binding efficacy compared with the reference inhibitor.Conclusion: This work identifies potential lead candidates for novel urease inhibitors, which with industrial support may be harnessed for the development of new drugs.