Correlation Between Swallowing and Cognitive Brain Networks in Older Adults via Functional MRI

作者：Jie Wang, Mengqing Zhang, Hongmei Wen, Cheng Yang, Xiaomei Wei, Yonghui Wang, Zulin Dou · 发表于：Journal of Oral Rehabilitation · 年份：2024 · DOI：10.1111/joor.13855 · 被引用次数：5 · 研究领域：Dysphagia Assessment and Management、Child Nutrition and Feeding Issues、Nutrition and Health in Aging

BACKGROUND: Clinical evidence supports that swallowing function is correlated with cognition, but the neurobiological mechanism associated with cognitive impairment and dysphagia remains unclear. OBJECTIVES: To compare the brain activation patterns of the swallowing and the cognitive tasks and explore neural associations between swallowing and cognitive function via task-related functional magnetic resonance imaging (fMRI). METHODS: A total of 13 healthy older adults (aged > 60 years) were recruited. Participants underwent the clinical dementia rating (CDR) test and the Montreal Cognitive Assessment (MoCA). A block-designed task-related fMRI study was conducted where each participant completed both swallowing and cognitive tasks within a single session. During the swallowing task, participants swallowed 2 mL of thickened water, while the Stroop Colour Word Test (SCWT) served as the cognitive task. First-level analysis of swallowing time-series images utilised the general linear model (GLM) with Statistical Parametric Mapping (SPM), applying a voxel threshold of p < 0.001 for significance. Common activations in brain regions during swallowing and cognitive tasks were extracted at the group level, with significance set at p < 0.05, corrected for multiple comparisons using the false discovery rate (FDR), with a minimum cluster size of 20 voxels. Correlation analysis between behavioural measurements and imaging signals was also conducted. RESULTS: Some regions were commonly activ...