Relationship of prefrontal cortex activity with anhedonia and cognitive function in major depressive disorder: an fNIRS study

作者：Huanhuan Fan, Qing Li, Yue Du, Yushun Yan, Rong‐Jun Ni, Jinxue Wei, Liansheng Zhao, Xiao Yang, Xiaohong Ma · 发表于：Frontiers in Psychiatry · 年份：2024 · DOI：10.3389/fpsyt.2024.1428425 · 被引用次数：10 · 研究领域：Optical Imaging and Spectroscopy Techniques、Neural and Behavioral Psychology Studies、Treatment of Major Depression

Background Major depressive disorder (MDD) is associated with deficits in cognitive function, thought to be related to underlying decreased hedonic experiences. Further research is needed to fully elucidate the role of functional brain activity in this relationship. In this study, we investigated the neurofunctional correlate of the interplay between cognitive function and hedonic experiences in medication-free MDD using functional near-infrared spectroscopy (fNIRS). Methods We examine differences of brain activation corresponding to the verbal fluency test (VFT) between MDD patients and healthy controls (HCs). Fifty-six MDD patients and 35 HCs underwent fMRI scanning while performing the VFT. In exploratory analyses, cognitive performance, as assessed by the Cambridge Neuropsychological Test Automated Battery (CANTAB), four dimensions of hedonic processing (desire, motivation, effort, and consummatory pleasure) measured by the Dimensional Anhedonia Rating Scale (DARS), and relative changes in oxygenated hemoglobin concentration during the VFT were compared across groups. Results Patients with MDD demonstrated impairments in sustained attention and working memory, accompanied by lower total and subscale scores on the DARS. Compared to healthy controls, MDD patients exhibited reduced activation in the prefrontal cortex (PFC) during the VFT task (t = 2.32 to 4.77, p < 0.001 to 0.02, FDR corrected). DARS motivation, desire, and total scores as well as sustained attention,...