Hypoxia-induced TGFBI maintains glioma stem cells by stabilizing EphA2

作者：Zirong Chen, Junhong Wang, Peng Peng, Guohao Liu, Minhai Dong, Xiaolin Zhang, Yang Zhang, Xue Yang, Li‐Jun Wan, Xiang Wang, Suojun Zhang, Bin Zhang, Qiuxia Wu, Xingjiang Yu, Feng Wan · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.95141 · 被引用次数：23 · 研究领域：Axon Guidance and Neuronal Signaling、Cancer, Hypoxia, and Metabolism、Neuroblastoma Research and Treatments

TGFBI plays a crucial role in maintaining the stem cell properties of GSCs in the hypoxic microenvironment. Targeting the TGFBI/EphA2 axis emerges as a promising and innovative strategy for GBM treatment, with the potential to improve the clinical outcomes of patients.