Pharmacological manipulation of TRPC5 by kaempferol attenuates metastasis of gastrointestinal cancer via inhibiting calcium involved in the formation of filopodia

作者：Suyun Yu, Rui Deng, Wei Wang, Defang Zou, Liang He, Zhonghong Wei, Yanhong Pan, Xiaoman Li, Yuanyuan Wu, Aiyun Wang, Wenxing Chen, Yang Zhao, Yin Lu · 发表于：International Journal of Biological Sciences · 年份：2024 · DOI：10.7150/ijbs.87829 · 被引用次数：10 · 研究领域：Lipoproteins and Cardiovascular Health

]i), driving actin cytoskeleton reorganization and facilitating filopodia formation. Furthermore, kaempferol, a compound sourced from traditional Chinese medicine, is identified as a TRPC5 inhibitor that effectively suppresses its activity, thereby impeding gastrointestinal cancer metastasis. These findings underscore the potential of TRPC5 as a therapeutic target for metastasis inhibition, with kaempferol emerging as a promising natural inhibitor that could be optimized for clinical use in preventing cancer metastasis.