Transcription Factor E2F4 Promote Proliferation, Migration, and Invasion of Gastric Cancer Cells by transcriptionally activating DSCC1

作者：Shantanu Baral, Yantao Yu, Qiannan Sun, Mingrui Jiang, Ruiqi Li, Yifan Cheng, Arawker Mubeen Hussein, Youquan Shi, Yongjun Jiang, Dong Tang, Sen Wang, Daorong Wang · 发表于：International Journal of Biological Sciences · 年份：2024 · DOI：10.7150/ijbs.99590 · 被引用次数：10 · 研究领域：RNA modifications and cancer

. Knockdown and overexpression experiments demonstrated that E2F4 positively regulates DSCC1 at the transcriptional level, with ChIP-qPCR and dual luciferase reporter assays validating the binding sites on the DSCC1 promoter. These findings highlight the E2F4-DSCC1 axis as a potential therapeutic target to mitigate GC progression.