SETD2 in cancer: functions, molecular mechanisms, and therapeutic regimens

作者：Yawen Weng, Jing Xue, Ningning Niu · 发表于：Cancer Biology and Medicine · 年份：2024 · DOI：10.20892/j.issn.2095-3941.2024.0201 · 被引用次数：10 · 研究领域：Endoplasmic Reticulum Stress and Disease、Ubiquitin and proteasome pathways、Ferroptosis and cancer prognosis

In recent years, the histone methyltransferase SET domain containing 2 (SETD2) has garnered significant attention for its involvement in carcinogenesis. Herein we aim to summarize the research advances regarding SETD2 in tumors, elucidate the role in global epigenetic regulation, highlight potential