Novel NIR-II 3,5-Julolidinyl aza-BODIPY for Photothermal Therapy of Gliomas Stem Cells by Brain Stereotactic Injection

作者：Lulu Cao, Zhiqiang Cui, Dongxiang Zhang, Yikun Li, Xiaoyan Gao, Rong Shang, Xin‐Dong Jiang, Jianjun Du, Xiaohong Sun · 发表于：ACS Materials Letters · 年份：2024 · DOI：10.1021/acsmaterialslett.4c01447 · 被引用次数：17 · 研究领域：Nanoplatforms for cancer theranostics、Luminescence and Fluorescent Materials、Advanced Nanomaterials in Catalysis

Functional dyes with absorption in the second near-infrared window (NIR-II) show great promise in photothermal therapy. Herein, the novel NIR-II 3,5-julolidinyl aza-BODIPY ( JLD ) was prepared and confirmed by X-ray crystallographic analysis for the first time. The molecular packing structure facilitates the J -aggregation packing mode. Self-assembled JLD -nanoparticles ( JLD -NPs) emit fluorescence (λ em = 962 nm, Φ f = 0.1%), and a peak belt covered a NIR-II range of 900–1300 nm. The photothermal conversion efficiency was high and was calculated to be 79%. JLD -NPs with NIR-II 915 nm laser irradiation had the good tumor-inhibition capability with promoting the apoptosis and inhibiting the stemness of glioblastoma cells by brain stereotactic injection and affect the occurrence of malignant events, such as migration and invasion.