Recent Advances in Anti-Inflammatory Compounds from Marine Microorganisms

作者：Guihua Yang, Miaoping Lin, Kumaravel Kaliaperumal, Yaqi Lu, Xin Qi, Xiaodong Jiang, Xinya Xu, Chenghai Gao, Yonghong Liu, Xiaowei Luo · 发表于：Marine Drugs · 年份：2024 · DOI：10.3390/md22090424 · 被引用次数：10 · 研究领域：Microbial Natural Products and Biosynthesis、Marine Sponges and Natural Products、Seaweed-derived Bioactive Compounds

Marine microbial secondary metabolites with diversified structures have been found as promising sources of anti-inflammatory lead compounds. This review summarizes the sources, chemical structures, and pharmacological properties of anti-inflammatory natural products reported from marine microorganisms in the past three years (2021-2023). Approximately 252 anti-inflammatory compounds, including 129 new ones, were predominantly obtained from marine fungi and they are structurally divided into polyketides (51.2%), terpenoids (21.0%), alkaloids (18.7%), amides or peptides (4.8%), and steroids (4.3%). This review will shed light on the development of marine microbial secondary metabolites as potential anti-inflammatory lead compounds with promising clinical applications in human health.