AMPK-PDZD8-GLS1 axis mediates calorie restriction-induced lifespan extension

作者：Mengqi Li, Yu Wang, Xiaoyan Wei, Wei-Feng Cai, Yan‐Hui Liu, Jianfeng Wu, Yan Chen, Jinye Xiong, Lifeng Cui, Mingxia Zhu, Cixiong Zhang, Cixiong Zhang, Liyun Lin, Yong Yu, Hai‐long Piao, Sheng‐Cai Lin, Chen‐Song Zhang, Chen‐Song Zhang · 发表于：Cell Research · 年份：2024 · DOI：10.1038/s41422-024-01021-3 · 被引用次数：15 · 研究领域：Genetics, Aging, and Longevity in Model Organisms、Dietary Effects on Health、Diet and metabolism studies

Calorie restriction (CR) that chronically reduces average daily caloric intake without causing malnutrition has been recognized as a non-pharmacological dietary behavior for improving health. 1 The benefits of CR have been observed in various species, including yeast, nematodes, mice, and primates, showing a general link between reduced food intake and longevity. 2 During CR, organisms undergo metabolic changes or adaptations, such as a shift from primarily consuming glucose to fatty acid and amino acid catabolism. 3 , 4 However, the mechanism behind these adaptations and their relationship to the lifespan extension mediated by CR remains largely unknown.