Incidence and Risk of Depressive Disorder in Patients With Retinitis Pigmentosa

作者：Hae Rang Kim, Nang Kyeong Lee, Youngsong Suh, Christopher Seungkyu Lee, Suk Ho Byeon, Sung Soo Kim, Seungwon Lee, Yong Joon Kim · 发表于：JAMA Ophthalmology · 年份：2024 · DOI：10.1001/jamaophthalmol.2024.3641 · 被引用次数：15 · 研究领域：Retinal Development and Disorders、Ophthalmology and Visual Impairment Studies、Ocular Disorders and Treatments

Importance: There is a lack of large-scale clinical studies exploring mental health among patients with retinitis pigmentosa (RP). Additionally, few studies have evaluated the associations of visual impairment with mental health in young patients. Objective: To investigate the association between depressive disorder and RP. Design, Setting, and Participants: This was a retrospective, nationwide, population-based cohort study using data obtained from the Health Insurance Review and Assessment service in Korea between 2008 and 2022. A total of 10 879 individuals who were newly diagnosed with RP between January 2011 and December 2021, as verified by both the RP registration code (National Registry of Rare and Intractable Disease in Korea code V209) and diagnostic code (International Statistical Classification of Diseases, 10th Revision code H35.51), were included. Data analysis was performed from October 2023 to January 2024. Exposure: Diagnosis of RP. Main Outcomes and Measures: Participants were categorized into 3 groups based on age at diagnosis (<20, 20-39, and ≥40 years). The incidence of depressive disorder in RP was determined after excluding those diagnosed with depressive disorder prior to RP diagnosis. Age- and sex-adjusted standardized incidence ratios (SIRs) of depressive disorder in patients with RP compared with the general population were calculated. Subgroup analyses by sex and age group were conducted. Results: A total of 10 879 patients (638 aged <20 years, 223...