Nickel-Catalyzed, Aminoquinoline-Directed Chemo- and Regioselective Carboamination of Unactivated Olefins with Organoboronic Acids and Anthranils

作者：Zhongke Xie, Yushan Cui, Jiale Xing, Yang Gao, Yanping Huo, Xianwei Li, Qian Chen · 发表于：The Journal of Organic Chemistry · 年份：2024 · DOI：10.1021/acs.joc.4c01536 · 被引用次数：9 · 研究领域：Catalytic C–H Functionalization Methods、Sulfur-Based Synthesis Techniques、Radical Photochemical Reactions

A nickel-catalyzed three-component carboamination of unactivated alkenes with organoboronic acids and anthranils has been achieved for the expedient synthesis of δ-aryl and γ-amino acid derivatives. The 8-aminoquinoline (AQ) directing group is crucial for the success of the reaction, and anthranil serves as an arylnitrene precursor in this conversion. This method features mild reaction conditions, good chemo- and regioselectivity, and a broad substrate scope with good functional group tolerance.