Microvascular alterations of the ocular surface and retina in connective tissue disease-related interstitial lung disease

作者：Liming Chen, Junyi Wang, San‐Hua Xu, Cheng Chen, Hong Wei, Qian Ling, Liang-Qi He, Jie Zou, Yixin Wang, Xu Chen, Ping Ying, Hui Huang, Yi Shao, Rui Wu · 发表于：International Journal of Ophthalmology · 年份：2024 · DOI：10.18240/ijo.2024.10.14 · 被引用次数：4 · 研究领域：Ocular Diseases and Behçet’s Syndrome、Retinal Imaging and Analysis、Retinal Diseases and Treatments

AIM: To examine the disparities in macular retinal vascular density between individuals with connective tissue disease-related interstitial lung disease (CTD-ILD) and healthy controls (HCs) by optical coherence tomography angiography (OCTA) and to investigate the changes in microvascular density in abnormal eyes. METHODS: For a retrospective case-control study, a total of 16 patients (32 eyes) diagnosed with CTD-ILD were selected as the ILD group. The 16 healthy volunteers with 32 eyes, matched in terms of age and sex with the patients, were recruited as control group. The macular retina’s superficial retinal layer (SRL) and deep retinal layer (DRL) were examined and scanned using OCTA in each individual eye. The densities of retinal microvascular (MIR), macrovascular (MAR), and total microvascular (TMI) were calculated and compared. Changes in retinal vascular density in the macular region were analyzed using three different segmentation methods: central annuli segmentation method (C1-C6), hemispheric segmentation method [uperior right (SR), superior left (SL), inferior left (IL), and inferior right (IR)], and Early Treatment Diabetic Retinopathy Study (ETDRS) methods [superior (S), inferior (I), left (L), and right (R)]. The data were analyzed using Version 9.0 of GraphPad prism and Pearson analysis. RESULTS: The OCTA data demonstrated a statistically significant difference (P<0.05) in macular retinal microvessel density between the two groups. Specifically, in the SRL and ...