Cross-cutting studies of per- and polyfluorinated alkyl substances (PFAS) in Arctic wildlife and humans

作者：Rainer Lohmann, Khaled Abass, Eva Cecilie Bonefeld‐Jørgensen, Rossana Bossi, Runé Dietz, Steve Ferguson, Kim J. Fernie, Philippe Grandjean, Dorte Herzke, Magali Houde, Mélanie Lemire, Robert J. Letcher, Derek C. G. Muir, Amila O. De Silva, Sonja Ostertag, Amy A. Rand, Jens Søndergaard, Christian Sonne, Elsie M. Sunderland, Katrin Vorkamp, Simon Wilson, Pál Weihe · 发表于：The Science of The Total Environment · 年份：2024 · DOI：10.1016/j.scitotenv.2024.176274 · 被引用次数：43 · 研究领域：Per- and polyfluoroalkyl substances research、Toxic Organic Pollutants Impact、Atmospheric chemistry and aerosols

This cross-cutting review focuses on the presence and impacts of per- and polyfluoroalkyl substances (PFAS) in the Arctic. Several PFAS undergo long-range transport via atmospheric (volatile polyfluorinated compounds) and oceanic pathways (perfluorinated alkyl acids, PFAAs), causing widespread contamination of the Arctic. Beyond targeting a few well-known PFAS, applying sum parameters, suspect and non-targeted screening are promising approaches to elucidate predominant sources, transport, and pathways of PFAS in the Arctic environment, wildlife, and humans, and establish their time-trends. Across wildlife species, concentrations were dominated by perfluorooctane sulfonic acid (PFOS), followed by perfluorononanoic acid (PFNA); highest concentrations were present in mammalian livers and bird eggs. Time trends were similar for East Greenland ringed seals ( Pusa hispida ) and polar bears ( Ursus maritimus ). In polar bears, PFOS concentrations increased from the 1980s to 2006, with a secondary peak in 2014–2021, while PFNA increased regularly in the Canadian and Greenlandic ringed seals and polar bear livers. Human time trends vary regionally (though lacking for the Russian Arctic), and to the extent local Arctic human populations rely on traditional wildlife diets, such as marine mammals. Arctic human cohort studies implied that several PFAAs are immunotoxic, carcinogenic or contribute to carcinogenicity, and affect the reproductive, endocrine and cardiometabolic systems. Physio...