Copper(0)-Catalyzed Reductive Coupling of Disulfurating Reagents and (Hetero)aryl/Alkyl Halides

作者：Wang Chen, Jiuwen Xu, Weidong Rao, Shusu Shen, Zhao‐Ying Yang, Lutz Ackermann, Shun‐Yi Wang · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c03032 · 被引用次数：10 · 研究领域：Sulfur-Based Synthesis Techniques、Chemical Synthesis and Reactions、Catalytic C–H Functionalization Methods

Herein, we reported a copper(0)-catalyzed reductive coupling of disulfurating reagents and (hetero)aryl/alkyl halides. Copper(0) can be directly inserted into tetrasulfide and then undergoes reductive coupling with (hetero)aryl Iodides to construct disulfide. The method features the unprecedented use of copper(0)-catalyzed disulfurating reagents (tetrasulfides) in cross-coupling chemistry and is convenient with broad substrate scopes, even applicable to different halogenated hydrocarbons. It is worth noting that the methodology is practical with the late-stage modification of bioactive scaffolds of pharmaceuticals. In the meantime, the synthesis of disulfides is successfully achieved on a gram scale, indicating the approach is highly valuable.