Acceptance of emerging renal oncocytic neoplasms: a survey of urologic pathologists

作者：Sambit K. Mohanty, Anandi Lobo, Shilpy Jha, Ankur R. Sangoi, Mahmut Akgül, Kiril Trpkov, Ondřej Hes, Rohit Mehra, Michelle S. Hirsch, Holger Moch, Steven C. Smith, Rajal B. Shah, Liang Cheng, Mahul B. Amin, Jonathan I. Epstein, Anil V. Parwani, Brett Delahunt, Sangeeta Desai, Christopher G. Przybycin, Claudia Manini, Daniel Luthringer, Deepika Sirohi, Deepika Jain, Divya Midha, Ekta Jain, Fiona Maclean, Giovanna A. Giannico, Gladell P. Paner, Guido Martignoni, Hikmat Al‐Ahmadie, Jesse K. McKenney, John R. Srigley, José I. López, Lakshmi P. Kunju, Lisa Browning, Manju Aron, Maria M. Picken, Maria Tretiakova, Ming Zhou, Mukund Sable, Naoto Kuroda, Niharika Pattnaik, Nilesh Gupta, Priya Rao, Samson W. Fine, Pritinanda Mishra, Amit Kumar Adhya, Bijal Kulkarni, Mallika Dixit, Manas Baisakh, Samriti Arora, Sankalp Sancheti, Santosh Menon, Sara E. Wobker, Satish K. Tickoo, Seema Kaushal, Shailesh Soni, Shivani Kandukuri, Shivani Sharma, Suvradeep Mitra, Victor E Reuter, Vipra Malik, Vishal Rao, Ying‐Bei Chen, Sean R. Williamson · 发表于：Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · 年份：2024 · DOI：10.1007/s00428-024-03909-2 · 被引用次数：6 · 研究领域：Renal cell carcinoma treatment、Bladder and Urothelial Cancer Treatments、Urinary and Genital Oncology Studies

Oncocytic renal neoplasms are a major source of diagnostic challenge in genitourinary pathology; however, they are typically nonaggressive in general, raising the question of whether distinguishing different subtypes, including emerging entities, is necessary. Emerging entities recently described include eosinophilic solid and cystic renal cell carcinoma (ESC RCC), low-grade oncocytic tumor (LOT), eosinophilic vacuolated tumor (EVT), and papillary renal neoplasm with reverse polarity (PRNRP). A survey was shared among 65 urologic pathologists using SurveyMonkey.com (Survey Monkey, Santa Clara, CA, USA). De-identified and anonymized respondent data were analyzed. Sixty-three participants completed the survey and contributed to the study. Participants were from Asia (n = 21; 35%), North America (n = 31; 52%), Europe (n = 6; 10%), and Australia (n = 2; 3%). Half encounter oncocytic renal neoplasms that are difficult to classify monthly or more frequently. Most (70%) indicated that there is enough evidence to consider ESC RCC as a distinct entity now, whereas there was less certainty for LOT (27%), EVT (29%), and PRNRP (37%). However, when combining the responses for sufficient evidence currently and likely in the future, LOT and EVT yielded > 70% and > 60% for PRNRP. Most (60%) would not render an outright diagnosis of oncocytoma on needle core biopsy. There was a dichotomy in the routine use of immunohistochemistry (IHC) in the evaluation of oncocytoma (yes = 52%; no = 48%). Th...