Photocatalytic Regioselective Redox-Neutral 1,3-Oxypyridylation of Aryl Cyclopropanes

作者：Dongjie Li, Xia-Ling Liu, You-Zhi Liao, Yi Zhao, Fei Pan · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c02918 · 被引用次数：13 · 研究领域：Cyclopropane Reaction Mechanisms、Catalytic C–H Functionalization Methods、Sulfur-Based Synthesis Techniques

Pyridines and cyclopropanes are important structural units in chemistry. Herein, we introduce a photoredox-catalyzed approach for the ring opening and 1,3-oxypyridylation of aryl cyclopropanes using 4-cyanopyridines and carboxylic acids. This sequential process involves single-electron oxidation of the aryl cyclopropane, leading to nucleophilic ring opening and radical pyridylation at the benzylic position. The redox-neutral reaction exhibits high regioselectivity under mild reaction conditions, offering a broad substrate scope and wide applicability.