Reference values for exhaled nitric oxide in healthy children aged 6–18 years in China: a cross-sectional, multicenter clinical study

作者：Yazun Liu, Hao Zhang, JinRong Wang, Yuling Han, Chunhong Pan, Wenhui Jiang, Chun-yan Ma, Yongsheng Shi, Chunmei Jia, Yuehua Zhang, Min Li, Fei Wang, Yanyan Yu, Yong Feng, Li Liu, Aihong Liu, Qiaoling Zhang, Zhen Long, Fuli Dai, Yanli Zhang, Minghong Ji, Dongjun Ma · 发表于：Respiratory Research · 年份：2024 · DOI：10.1186/s12931-024-02938-4 · 被引用次数：6 · 研究领域：Asthma and respiratory diseases、Nitric Oxide and Endothelin Effects、Chronic Obstructive Pulmonary Disease (COPD) Research

The reference values of eNO have certain differences among people of different countries and races. We aimed to obtain the reference value of eNO in healthy children and adolescents (6–18 years old) in China and to explore the associations between the reference values with ages, gender, heights, BMI, and regions. We measured FeNO 50 levels in 5949 healthy Chinese children and adolescents, FeNO 200 and CaNO levels in 658 participants from 16 provinces of 7 administrative areas in China aged 6–18. All persons were studied after obtaining informed consent from children and their parents. The mean FeNO 50 of 5949 Chinese children and adolescents aged 6–18 years was 14.1 ppb, with a 95% confidence interval of 1-38.1 ppb. The mean FeNO 200 of 658 persons was 6.9 ppb with a 95% upper confidence interval of 15.0 ppb, and the mean CaNO was 3.0 ppb with a 95% upper confidence interval of 11.2 ppb. In the 6–11 age group, age and height were correlated with the logarithm of FeNO 50 ( P < 0.001, P < 0.05). There was no significant correlation between the logarithm of FeNO 200 and gender, age, height and BMI (all P > 0.05). The logarithm of CaNO was correlated with gender ( P < 0.05). In the 12–18 age group, gender, height, and region were correlated with the logarithm of FeNO 50 (all P < 0.001). There was only a weak correlation between the logarithm of FeNO 200 and height ( P < 0.001). The logarithm of CaNO was negatively correlated with age ( P < 0.05). Higher FeNO 50 , FeNO 200 and CaN...