Phenotypic age mediates effects of Life's Essential 8 on reduced mortality risk in US adults

作者：Yuxuan Zhao, Yang Haiming, Rong Jiao, Yueqing Wang, Meng Xiao, Mingyu Song, Huan Yu, Chunxiao Liao, Yuanjie Pang, Wenjing Gao, Tao Huang, Canqing Yu, Jun Lv, Shengxu Li, Lu Qi, Liming Li, Dianjianyi Sun · 发表于：Precision Clinical Medicine · 年份：2024 · DOI：10.1093/pcmedi/pbae019 · 被引用次数：6 · 研究领域：Genetics, Aging, and Longevity in Model Organisms、Cardiovascular Health and Risk Factors、Aging and Gerontology Research

Abstract Objective This study aimed to find out whether phenotypic age could mediate the protective effects of a healthy lifestyle on mortality. Methods We included adult participants with available data for individual phenotypic age (PhenoAge) and Life's Essential 8 (LE8) scores from the National Health and Nutrition Examination Survey 2005–2010 (three cycles) and linked mortality records until 31 December 2019. Adjusted hazard ratios (HR) were estimated to evaluate the associations of PhenoAge and LE8 scores with all-cause and cardiovascular mortality risk. Mediation analyses were performed to estimate the proportional contribution of PhenoAge to the effect of LE8 on mortality risks. Results A 1-year increment in PhenoAge was associated with a higher risk of all-cause (HR = 1.04 [95% confidence interval, 1.04–1.05]) and cardiovascular (HR = 1.04 [95% confidence interval, 1.04–1.05]) mortality, independent of chronological age, demographic characteristics, and disease history. High level of LE8 (score: 80–100) was associated with a 3.30-year younger PhenoAge. PhenoAge was estimated to mediate 36 and 22% of the effect of LE8 on all-cause and cardiovascular mortality, respectively (all P < 0.001). As for single-metric scores of LE8, PhenoAge mediated 30%, 11%, 9%, and 7% of the effects of the healthy diet, smoking status, blood pressure, and physical activity on all-cause mortality risk, respectively (all P < 0.05). Conclusion Adherence to LE8 recommendations slo...