Sorafenib and SIAIS361034, a novel PROTAC degrader of BCL-xL, display synergistic antitumor effects on hepatocellular carcinoma with minimal hepatotoxicity

作者：Xiaoyi Zhang, Yachuan Tao, Zhongli Xu, Biao Jiang, Xiaobao Yang, Taomin Huang, Wenfu Tan · 发表于：Biochemical Pharmacology · 年份：2024 · DOI：10.1016/j.bcp.2024.116542 · 被引用次数：5 · 研究领域：Protein Degradation and Inhibitors、Peptidase Inhibition and Analysis、Multiple Myeloma Research and Treatments