Interactive effect of air pollution and genetic risk of depression on processing speed by resting-state functional connectivity of occipitoparietal network

作者：Yuyanan Zhang, Zhe Lu, Yaoyao Sun, Liangkun Guo, Xiaoli Zhang, Yundan Liao, Zhewei Kang, Xiaoyang Feng, Guorui Zhao, Junyuan Sun, Yang Yang, Hao Yan, Dai Zhang, Weihua Yue · 发表于：BMC Medicine · 年份：2024 · DOI：10.1186/s12916-024-03614-6 · 被引用次数：7 · 研究领域：Functional Brain Connectivity Studies、Air Quality and Health Impacts、Health, Environment, Cognitive Aging

Air pollution, a reversible environmental factor, was significantly associated with the cognitive domains that are impaired in major depressive disorder (MDD), notably processing speed. Limited evidence explores the interactive effect of air pollution and the genetic risk of depression on cognition. This cross-sectional study aims to extend the research by specifically examining how this interaction influences depression-related cognitive impairment and resting-state brain function. Eligible participants were 497 healthy adult volunteers (48.7% males, mean age 24.5) living in Beijing for at least 1 year and exposed to relatively high air pollution from the local community controlling for socioeconomic and genomic. Six months’ ambient air pollution exposures were assessed based on residential addresses using monthly averages of fine particulate matter with a diameter of less than or equal to 2.5 μm (PM 2.5 ). A cross-sectional analysis was conducted using functional magnetic resonance imaging (fMRI) and cognitive performance assessments. The polygenic risk score (PRS) of MDD was used to estimate genetic susceptibility. Using a general linear model and partial least square regression, we observed a negative association between resting-state local connectivity in precuneus and PRS-by-PM 2.5 interactive effect ( P FWE = 0.028), indicating that PM 2.5 exposure reduced the spontaneous activity in precuneus in individuals at high genetic risk for MDD. DNA methylation and gene expres...