Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy

作者：Jeremy Baldwin, Christoph Heuser-Loy, Tanmoy Saha, Roland Christian Schelker, Dragana Slavkovic‐Lukic, Nicholas Strieder, Inmaculada Hernandez-Lopez, Nisha Rana, Markus Barden, Fabio Mastrogiovanni, Azucena Martín-Santos, Andrea Raimondi, Philip Z. Brohawn, Brandon W. Higgs, Claudia Gebhard, Veena Kapoor, William G. Telford, Sanjivan Gautam, Maria Xydia, Philipp Beckhove, Sina Frischholz, Kilian Schober, Zacharias Kontarakis, Jacob E. Corn, Matteo Iannacone, Donato Inverso, Michael Rehli, Jessica Fioravanti, Shiladitya Sengupta, Luca Gattinoni · 发表于：Cell · 年份：2024 · DOI：10.1016/j.cell.2024.08.029 · 被引用次数：247 · 研究领域：Graphene and Nanomaterials Applications、CAR-T cell therapy research、Nanoplatforms for cancer theranostics

T cells mediated superior antitumor responses, prolonging animal survival. These findings establish intercellular mitochondrial transfer as a prototype of organelle medicine, opening avenues to next-generation cell therapies.