Evaluation of apparent diffusion coefficient (ADC) with regards to reproducibility and diagnostic accuracy as well as possible significance of pre - and post - contrast acquisition and employment of different b values

作者：Raoul Varga, Barbara J. Fueger, Francesca Ferrara, Panagiotis Kapetas, Nina Pötsch, Thomas H. Helbich, Paola Clauser, Pascal Baltzer · 发表于：European Journal of Radiology · 年份：2024 · DOI：10.1016/j.ejrad.2024.111730 · 被引用次数：1 · 研究领域：MRI in cancer diagnosis、Advanced Neuroimaging Techniques and Applications、Digital Radiography and Breast Imaging

PURPOSE: Ongoing efforts are focusing on optimizing diffusion-weighted imaging (DWI) as an essential part of breast MRI protocol. Our study aimed to evaluate the effect of contrast media (CM) on the apparent diffusion coefficients (ADC) acquired following current recommendations. PATIENT AND METHODS: Patients who underwent 3 T breast MRI with a histologically verified suspicious lesion were included in this IRB-approved, single-center, cross-sectional retrospective study. Breast MRI protocol included a DWI sequence with multiple b-values, which was acquired before and after CM administration. ADC maps were calculated by in-line monoexponential fitting with b-values 0 /800 and 50/800. Two independent readers (R1, R2) reviewed the images in separate sessions for b values 0/800 and 50/800, pre- and post-CM. Bland Altmann plots as well as intraclass correlation coefficients (ICCs) for inter-reader agreement, different b-values, and pre- and post-CM were calculated. Diagnostic accuracy was evaluated and compared by calculating the area under the receiver operating characteristics curve (AUC). RESULTS: ). We found an almost perfect inter-reader agreement pre-/post-CM with b values 0/800 and 50/800 (ICC ranging from 0.853 to 0.939). Bland Altman plot demonstrated no systematic difference between readers. ROC analysis revealed good diagnostic performance without significant differences (P>0.05) between b values 0/800 and 50/800 s/mm2 as well as pre- and post-CM with areas under the R...