Antifungal Activity of Phloroglucinol Derivatives against Botrytis cinerea and Monilinia fructicola

作者：Chen-Xin Jing, Yongmei Hu, Ya‐Rui Jin, An‐Ping Li, Rui Wang, Shaoyong Zhang, Zhengrong Wu, Xiaoyu Yan, Zhijun Zhang, Hongjie Liang, Jun‐Xia An, Ying‐Qian Liu · 发表于：Journal of Agricultural and Food Chemistry · 年份：2024 · DOI：10.1021/acs.jafc.4c05968 · 被引用次数：14 · 研究领域：Natural Compound Pharmacology Studies、Fungal Plant Pathogen Control、Allelopathy and phytotoxic interactions

Naturally derived compounds show promise as treatments for microbial infections. Polyphenols, abundantly found in various plants, fruits, and vegetables, are noted for their physiological benefits including antimicrobial effects. This study introduced a new set of acylated phloroglucinol derivatives, synthesized and tested for their antifungal activity in vitro against seven different pathogenic fungi. The standout compound, 3-methyl-1-(2,4,6-trihydroxyphenyl) butan-1-one ( 2b ), exhibited remarkable fungicidal strength, with EC 50 values of 1.39 μg/mL against Botrytis cinerea and 1.18 μg/mL against Monilinia fructicola, outperforming previously screened phenolic compounds. When tested in vivo, 2b demonstrated effective antifungal properties, with cure rates of 76.26% for brown rot and 83.35% for gray mold at a concentration of 200 μg/mL, rivaling the commercial fungicide Pyrimethanil in its efficacy against B. cinerea . Preliminary research suggests that 2b’ s antifungal mechanism may involve the disruption of spore germination, damage to the fungal cell membrane, and leakage of cellular contents. These results indicate that compound 2b has excellent fungicidal properties against B. cinerea and holds potential as a treatment for gray mold.