Post-conization pathological upgrading and outcomes of 466 patients with low-grade cervical intraepithelial neoplasia

作者：Yulin Guo, Hongning Cai, Qiuzi Peng, Ying Wang, Lu Li, Miao Zou, Jinyue Guo, Chaonan Wang, Xufeng Wu, Quanfu Ma · 发表于：Frontiers in Oncology · 年份：2024 · DOI：10.3389/fonc.2024.1449080 · 研究领域：Cervical Cancer and HPV Research、Endometrial and Cervical Cancer Treatments、Reproductive tract infections research

Introduction The management of patients with low-grade cervical intraepithelial neoplasia (CIN1) remains controversial. We analyzed the pathological upgrading rates of patients with CIN1 undergoing conization, identifying influencing factors, and compared their outcomes to those of patients with CIN1 receiving follow-up only. Methods This retrospective study included 466 patients with CIN1 confirmed by histopathology and treated with conization. Postoperative pathological upgrading was determined and its influencing factors were identified. We also analyzed post-conization outcomes, examining the rate of persistent/recurrent CIN1 and its influencing factors, and comparing these results to those of patients receiving follow-up only. Results The pathological upgrading rate of patients with CIN1 after conization was 21.03% (98/466), and the influencing factors were preoperative high-risk human papillomavirus (HR-HPV) infection and cytological results. The upgrading rates of HR-HPV positive and negative patients were 22.05% and 0.00%, respectively ( χ 2 = 5.03, P =0.03). The upgrading rate of patients with cytological results negative for intraepithelial lesion malignancy was 10.94%, while the upgrading rates of atypical squamous cells, cannot exclude high-grade lesion(ASC-H) and high-grade squamous intraepithelial lesion(HSIL) groups were 47.37% and 52.94%, respectively ( χ 2 = 22.7, P =0.03). Persistent/recurrent CIN1 rates in the conization group were 21.24%, 15.97%, and 6.67%...