Sarcopenia as a predictor of nutritional status and comorbidities: a cross-sectional and mendelian randomization study

作者：Chao Liu, Guanyi Chen, Yu Xia, Pingxiao Wang, Ziyue Zhao, Jialin Zhang, Tao Xiao, Hui Li · 发表于：BMC Geriatrics · 年份：2024 · DOI：10.1186/s12877-024-05341-2 · 被引用次数：2 · 研究领域：Nutrition and Health in Aging、Genetic Associations and Epidemiology、Bone health and osteoporosis research

BACKGROUND: With the advancement of world population aging, age-related sarcopenia (SP) imposes enormous clinical burden on hospital. Clinical research of SP in non-geriatric wards has not been appreciated, necessitating further investigation. However, observational studies are susceptible to confounders. Mendelian randomization (MR) can effectively mitigate bias to assess causality. OBJECTIVE: To investigate the correlation between SP and comorbidities in orthopedic wards, and subsequently infer the causality, providing a theoretical basis for developing strategies in SP prevention and treatment. METHODS: Logistic regression models were employed to assess the correlation between SP and comorbidities. The MR analysis was mainly conducted with inverse variance weighted, utilizing data extracted from the UK and FinnGen biobank (Round 9). RESULTS: In the cross-sectional analysis, SP exhibited significant associations with malnutrition (P = 0.013) and some comorbidities, including osteoporosis (P = 0.014), body mass index (BMI) (P = 0.021), Charlson Comorbidity Index (CCI) (P = 0.006). The MR result also provided supporting evidence for the causality between SP and hypertension, osteoporosis and BMI. These results also withstood multiple sensitivity analyses assessing the validity of MR assumptions. CONCLUSION: The result indicated a significant association between SP and BMI, CCI, malnutrition, and osteoporosis. We highlighted that SP and comorbidities deserved more attention in...