Association Between Genetically Determined Serum Corin and the Risk of Stroke in Chinese Adults: A Mendelian Randomization Study

作者：Yang Liu, Linan Chen, Guozhe Sun, Hao Zhang, Wenqing Geng, Xinwei Li, Qiu Zhang, Yibing Jin, Jialing Yao, Xiangdong Yang, Wenxiu Fan, Jiexiang Jing, Shuyao Wang, Hao Peng · 发表于：Journal of the American Heart Association · 年份：2024 · DOI：10.1161/jaha.124.035858 · 被引用次数：5 · 研究领域：Folate and B Vitamins Research、Saffron Plant Research Studies、Plant Micronutrient Interactions and Effects

Background Serum corin has been associated with stroke in observational studies, but the underlying causality is uncertain. This study examined the causal association between corin and stroke through Mendelian randomization study. Methods and Results In the Gusu cohort, serum corin was assayed at baseline, and stroke incidents were prospectively obtained during 10 years of follow‐up. Single‐nucleotide polymorphisms (SNPs) in CORIN were genotyped by MassArray for 2310 participants (mean age, 53 years; 39% men). Seventeen SNPs passed the Hardy–Weinberg test and were considered the potential instruments. Only 1 SNP (rs2271037) determined variability of serum corin was significantly associated with stroke even after adjusting for conventional risk factors (hazard ratio [HR], 1.36 [95% CI, 1.00–1.85]). The weighted genetic risk score generated from the SNP‐corin associations was significantly associated with stroke (HR, 2.01 [95% CI, 1.15–3.51]). Using this genetic risk score as the instrument, 1‐sample Mendelian randomization analysis found a significant HR of stroke per‐SD higher log 2 ‐transformed corin (HR, 1.37 [95% CI, 1.07–1.76]). The inverse variance–weighted analysis based on the SNP‐corin and SNP‐stroke associations found that the HR of stroke pre‐SD higher log 2 ‐transformed corin was 5.92 (95% CI, 2.23–15.72). The effect estimates stayed consistent regardless of an individual SNP being removed from the instruments. An almost identical effect estimate was also confirmed...