Contracted functional connectivity profiles in autism

作者：Clara F. Weber, Valeria Kebets, Oualid Benkarim, Sara Larivière, Yezhou Wang, Alexander Ngo, Hongxiu Jiang, Xiaoqian J. Chai, Bo‐yong Park, Michael P. Milham, Adriana Di Martino, Sofie L. Valk, Seok‐Jun Hong, Boris C. Bernhardt · 发表于：Molecular Autism · 年份：2024 · DOI：10.1186/s13229-024-00616-2 · 被引用次数：19 · 研究领域：Functional Brain Connectivity Studies、Neural dynamics and brain function、Mental Health Research Topics

OBJECTIVE: Autism spectrum disorder (ASD) is a neurodevelopmental condition that is associated with atypical brain network organization, with prior work suggesting differential connectivity alterations with respect to functional connection length. Here, we tested whether functional connectopathy in ASD specifically relates to disruptions in long- relative to short-range functional connections. Our approach combined functional connectomics with geodesic distance mapping, and we studied associations to macroscale networks, microarchitectural patterns, as well as socio-demographic and clinical phenotypes. METHODS: We studied 211 males from three sites of the ABIDE-I dataset comprising 103 participants with an ASD diagnosis (mean ± SD age = 20.8 ± 8.1 years) and 108 neurotypical controls (NT, 19.2 ± 7.2 years). For each participant, we computed cortex-wide connectivity distance (CD) measures by combining geodesic distance mapping with resting-state functional connectivity profiling. We compared CD between ASD and NT participants using surface-based linear models, and studied associations with age, symptom severity, and intelligence scores. We contextualized CD alterations relative to canonical networks and explored spatial associations with functional and microstructural cortical gradients as well as cytoarchitectonic cortical types. RESULTS: Compared to NT, ASD participants presented with widespread reductions in CD, generally indicating shorter average connection length and thu...