CD8 + tissue-resident memory T cells are essential in bleomycin-induced pulmonary fibrosis

作者：Xiao Feng, Fan Yu, Xin‐Liang He, Peipei Cheng, Qian Niu, Liqin Zhao, Qian Li, Xiao-Lin Cui, Zi-Heng Jia, Shu-Yi Ye, Limei Liang, Linjie Song, Liang Xiong, Fei Xiang, Xiaorong Wang, Wan-Li Ma, Hong Ye · 发表于：American Journal of Physiology-Cell Physiology · 年份：2024 · DOI：10.1152/ajpcell.00368.2024 · 被引用次数：13 · 研究领域：Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis、Cancer Immunotherapy and Biomarkers、Antifungal resistance and susceptibility

The role of CD8 + T RM cells in the development of pulmonary fibrosis was validated and studied in the classic model of pulmonary fibrosis. It was proposed for the first time that CCL18 has a chemotactic effect on CD8 + T RM cells, thereby exacerbating pulmonary fibrosis.