Spherical echo‐planar time‐resolved imaging (sEPTI) for rapid 3D quantitative T2* and susceptibility imaging

作者：Nan Wang, Congyu Liao, Xiaozhi Cao, Mark Nishimura, Yannick Brackenier, Mahmut Yurt, Mengze Gao, Daniel P. Abraham, Cagan Alkan, Siddharth Iyer, Zihan Zhou, Hwihun Jeong, Adam B. Kerr, Justin P. Haldar, Kawin Setsompop · 发表于：Magnetic Resonance in Medicine · 年份：2024 · DOI：10.1002/mrm.30255 · 被引用次数：10 · 研究领域：Advanced MRI Techniques and Applications、Microwave Imaging and Scattering Analysis、Medical Imaging Techniques and Applications

Abstract Purpose To develop a 3D spherical EPTI (sEPTI) acquisition and a comprehensive reconstruction pipeline for rapid high‐quality whole‐brain submillimeter and QSM quantification. Methods For the sEPTI acquisition, spherical k‐space coverage is utilized with variable echo‐spacing and maximum k x ramp‐sampling to improve efficiency and signal incoherency compared to existing EPTI approaches. For reconstruction, an iterative rank‐shrinking B 0 estimation and odd‐even high‐order phase correction algorithms were incorporated into the reconstruction to better mitigate artifacts from field imperfections. A physics‐informed unrolled network was utilized to boost the SNR, where 1‐mm and 0.75‐mm isotropic whole‐brain imaging were performed in 45 and 90 s at 3 T, respectively. These protocols were validated through simulations, phantom, and in vivo experiments. Ten healthy subjects were recruited to provide sufficient data for the unrolled network. The entire pipeline was validated on additional five healthy subjects where different EPTI sampling approaches were compared. Two additional pediatric patients with epilepsy were recruited to demonstrate the generalizability of the unrolled reconstruction. Results sEPTI achieved 1.4 faster imaging with improved image quality and quantitative map precision compared to existing EPTI approaches. The B 0 update and the phase correction provide improved reconstruction performance with lower artifacts. The unrolled network boosted the SNR, ac...