[18F]AlF-PSMA-11 PET in diagnosing prostate cancer: a head-to-head comparison with [68Ga]Ga-PSMA-11 PET and an exploration of dual-phase scanning

作者：Xiao Li, Mingming Yu, Jian Yang, Danni Li, Rou Li, Juanli Mao, Changjing Zuo, Zeying Liang, Qiang Li, Chao Cheng · 发表于：EJNMMI Reports · 年份：2024 · DOI：10.1186/s41824-024-00217-5 · 被引用次数：7 · 研究领域：Prostate Cancer Treatment and Research、Radiopharmaceutical Chemistry and Applications、Peptidase Inhibition and Analysis

Abstract Purpose To evaluate the physiological distribution and tumour detection ability of [ 18 F]AlF-PSMA-11 positron emission tomography (PET) dual-phase scans in patients with prostate cancer (PCa). Methods As a retrospective study, clinical and PET data of PCa patients who underwent dual-phase [ 18 F]AlF-PSMA-11 PET of routine scan (45–50 min) and delayed scan (120 min) from November 2020 to June 2021 were collected, and physiological and pathological regions of interest were quantified to determine the time-dependent maximum standardized uptake value (SUV max ) of [ 18 F]AlF-PSMA-11. Part of the above subjects who underwent [ 68 Ga]Ga-PSMA-11 PET in the following 6 months were included in a head-to-head comparison. The difference with a p-value < 0.05 was defined as statistical significance. Diagnosis accuracy of primary and metastatic lesions was measured referring to the surgical findings, pathology, and follow-up imaging. Results [ 68 Ga]Ga-PSMA-11 and [ 18 F]AlF-PSMA-11 were of the comparable uptake in glands in head, but the latter was of a significant lower distribution in liver and spleen. For the 25 patients initially diagnosed with prostate cancer and 3 patients with biochemical recurrence after radical surgery, the SUV max of the primary lesions, lacrimal glands, parotid glands and submandibular glands was higher at 120 min compared to that at 45–50 min, but not a significant difference. SUV max of the liver, spleen and bladder decreased significantly at 12...